Table 3.

Glucose control performances of different designs evaluated for pregnancy glycemic targets across all in-silico subjects.

Scenario	% Time < 54 mg/dL			% Time < 63 mg/dL			% Time 63-140 mg/dL			% Time > 140 mg/dL
	BL	ZA	PS	BL	ZA	PS	BL	ZA	PS	BL	ZA	PS
A.1	0.03	0.05	0.16	0.06	0.26	0.58	85.32	90.67	91.34	14.63	9.07	8.08
A.2	0.04	0.07	0.11	0.07	0.42	0.61	89.9	94.33	95.20	10.03	5.25	4.19
B.1.a	0.01	0.03	0.05	0.03	0.05	0.22	76.19	83.14	86.78	23.79	16.81	13.00
B.1.b	0.03	0.03	0.04	0.03	0.10	0.16	79.24	86.9	91.72	20.72	13.00	8.12
B.2.a	0.00	0.00	0.00	0.00	0.00	0.02	61.78	69.77	76.36	38.22	30.23	23.63
B.2.b	0.00	0.00	0.01	0.00	0.03	0.03	63.48	71.89	79.88	36.52	28.08	20.10
B.3.a	0.45	0.48	0.51	1.77	1.82	1.99	75.65	82.72	84.84	22.58	15.46	13.17
B.3.b	0.00	0.02	0.04	0.01	0.05	0.22	69.82	77.53	81.36	30.17	22.42	18.42
C.1	0.00	0.02	0.02	0.00	0.06	0.05	67.96	70.51	76.3	32.04	29.43	23.66
C.2	0.00	0.02	0.02	0.00	0.06	0.07	69.65	72.47	79.9	30.35	27.47	20.02
D.1	2.09	2.43	3.17	3.95	5.17	6.78	87.63	89.86	88.86	8.42	4.97	4.36
D.2	0.00	0.00	0.00	0.00	0.00	0.01	33.9	46.15	55.47	66.1	53.85	44.52
D.3	0.00	0.02	0.02	0.00	0.06	0.05	56.76	58.78	63.4	43.24	41.16	36.55

Poorest Performance Highest Performance*

BL, Baseline; ZA, Zone-Adjusted; PS, Pregnancy Specific.

*Color codes are applied separately for each glycemic metric to help the evaluation of performances across scenarios and designs.

Statistically significant differences between zone-adjusted and pregnancy-specific controller performances are marked with bold. P-values for all metrics and scenarios can be found in the Supplementary Material.