Table 4.

Glucose control performances of different designs evaluated for standard glycemic targets across all in-silico subjects.

Scenario	% Time < 70 mg/dL				% Time 70-180 mg/dL				% Time > 180 mg/dL				% Time > 250 mg/dL
	BL	ZA	PS		BL	ZA	PS		BL	ZA	PS		BL	ZA	PS
A.1	0.17	1.09	1.74		99.01	98.57	98.1		0.83	0.34	0.16		0.00	0.00	0.00
A.2	0.24	1.49	2.04		99.42	98.37	97.89		0.34	0.14	0.06		0.00	0.00	0.00
B.1.a	0.04	0.36	0.71		98.63	98.96	98.93		1.34	0.68	0.36		0.00	0.00	0.00
B.1.b	0.04	0.41	0.63		99.29	99.29	99.25		0.67	0.3	0.12		0.00	0.00	0.00
B.2.a	0.00	0.06	0.08		96.19	97.57	98.83		3.81	2.37	1.09		0.01	0.00	0.00
B.2.b	0.02	0.07	0.08		97.33	98.44	99.25		2.65	1.5	0.67		0.00	0.00	0.00
B.3.a	3.04	3.39	3.66		95.38	95.81	95.80		1.58	0.79	0.54		0.00	0.00	0.00
B.3.b	0.03	0.30	0.74		98.58	98.69	98.45		1.40	1.00	0.81		0.00	0.00	0.00
C.1	0.02	0.18	0.18		98.04	98.34	99.13		1.94	1.48	0.69		0.00	0.00	0.00
C.2	0.03	0.24	0.30		98.76	98.79	99.3		1.21	0.97	0.40		0.00	0.00	0.00
D.1	5.56	8.00	10.46		94.14	91.86	89.49		0.30	0.14	0.05		0.00	0.00	0.00
D.2	0.00	0.00	0.03		85.48	89.99	94.77		14.52	10.01	5.20		0.02	0.01	0.01
D.3	0.02	0.20	0.18		91.64	92.90	95.59		8.34	6.89	4.23		0.01	0.00	0.00

Poorest Performance Highest Performance*

BL, Baseline; ZA, Zone-Adjusted; PS, Pregnancy Specific.

*Color codes are applied separately for each glycemic metric to help the evaluation of performances across scenarios and designs.

Statistically significant differences between zone-adjusted and pregnancy-specific controller performances are marked with bold. P-values for all metrics and scenarios can be found in the Supplementary Material.