ADMET properties of the top 10 hits.

Compound	Absorption		Distribution	Metabolism	Excretion	Toxicity
	GI absorption (%)	Water solubility	BBB/CNS permeation	CYP2D6 inhibitor	OCT2 substrate	AMES
Acetyldehydroanonaine	98.82	−5.01	No	No	No	Yes
Hydroxysanguinarine	100.00	−33.25	No	No	No	Yes
Stylopine	94.37	−2.70	No	Yes	No	No
Corysamine	85.01	−2.89	No	No	No	Yes
Irenolone	91.52	−4.61	No	No	No	Yes
Dehydroroemerine	98.22	−5.68	No	No	No	Yes
l-N-Acetylanonaine	96.87	−3.80	No	No	No	Yes
Dehydroevodiamines	99.69	−3.79	No	No	Yes	No
Elliptinone	93.49	−3.99	No	No	No	Yes
Chitranone	91.26	−4.38	No	No	No	Yes
Silmitasertib	99.25	−3.30	No	Yes	No	No
Wortmannin	100.00	−4.08	No	No	No	No