Table 4.

Mean ESAS items (mean, SD) and methadone dose (mg, mean, SD) in group H.

	T0	T7	T14	T30	T60	P intragroup
	n = 20	n = 18	n = 16	n = 15	n = 13
Pain	6.7 (2.1)	3.6 (1.6)	3.4 (2.0)	3.7 (1.9)	2.5 (1.7)	<.0005
Weakness	5.8 (3.0)	4.4 (2.2)	4.6 (3.0)	4.5 (2.2)	4.2 (2.6)	<.0005
Nausea	1.6 (2.2)	0.3 (0.8)	1.5 (2.8)	0.5 (1.6)	1.6 (3.0)	.011
Depression	3.8 (2.9)	2.1 (2.2)	2.2 (2.0)	2.0 (1.5)	3.7 (2.2)	<.0005
Anxiety	3.2 (3.6)	2.8 (2.4)	2.0 (2.2)	3.1 (2.6)	3.0 (2.5)	<.0005
Drowsiness	3.6 (3.1)	3.1 (2.7)	3.6 (3.2)	2.7 (2.8)	2.9 (2.5)	.001
Dyspnea	1.3 (2.4)	0.7 (1.4)	1.1 (1.7)	0.8 (1.4)	0.8 (1.2)	.04
Insomnia	4.0 (3.0)	1.1 (1.6)	1.2 (1.7)	1.7 (1.9)	0.9 (1.4)	<.0005
Poor appetite	3.6 (3.0)	1.6 (1.9)	2.2 (3.3)	0.7 (1.9)	2.2 (3.6)	<.0005
Poor well-being	4.7 (3.5)	2.1 (2.4)	2.8 (2.9)	2.7 (1.4)	2.5 (2.9)	.001
Total ESAS	38.4 (19.6)	21.7 (10.8)	25.2 (17.9)	22.5 (11.5)	25.2 (19.6)	<.0005
Methadone dose	9	10 (3.2)	11.2 (7.9)	11.7 (8.3)	10.5 (4.7)	.281