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. 2022 Feb 22;27(4):272–284. doi: 10.1093/oncolo/oyab048

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© The Author(s) 2022. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — The recent success of proteomics approaches is linked to the availability of next-generation mass spectrometers. The number of publications per year for different proteomics-related approaches was obtained from PubMed. (Inset) The term “proteome” was coined nearly a decade after the invention of the mass spectrometry (MS) principle. Since the advent of electron-spray ionization and matrix-assisted laser desorption ionization commercial mass spectrometers, the use of MS continues to increase, including the application of MS for protein investigation and, more specifically, proteomics. Main: Early adoption of MS-based proteomic techniques was dominated by 2D electrophoresis (gray), followed by targeted analysis using multiple/single reaction monitoring (MRM/SRM, pink). Since 2010, modern and comprehensive proteomic techniques such as tandem mass tag (blue) and data-independent acquisition (DIA/SWATH, red) have revolutionized the proteomics field.