Fig. 3. Effect of compounds 5e and 5d on tumor volume. Tested compounds were intraperitoneally injected to EAT mice for 20 days at 2.5 and 5 mg per kg per day. Tumor diameter of each mouse was monitored every 5 days from the first day of treatment (day 0) till day 20 using a digital vernier caliper. Data were presented as mean ± S.E.M of 8 mice for each group, *significant difference versus day 0, a–e significant difference of 5e (2.5 mg kg⁻¹), 5e (5 mg kg⁻¹), 5d (2.5 mg kg⁻¹), 5d (5 mg kg⁻¹), and doxorubicin, respectively, versus the corresponding EAT (statistical analysis was performed by two-way ANOVA, followed by the Tukey's multiple comparison test; at p < 0.05).