Tumor indices and TGI% of EAT control and treated mice. Tested compounds were intraperitoneally injected to EAT mice for 20 days at 2.5 and 5 mg per kg per day. Tumor indices values were presented as mean ± S.E.M of 5 mice for each group. *Significant difference versus EAT (statistical analysis was performed by one-way ANOVA, followed by the Tukey's multiple comparison test; at p < 0.05). TGI (%); tumor growth inhibition percentage.
| Parameters/groups | TGI (%) | Tumor index |
|---|---|---|
| EAT | 0 | 0.12 ± 0.006 |
| 5d (2.5 mg per kg per day) | 56.9 | 0.13 ± 0.002 |
| 5d (5 mg per kg per day) | 72.3 | 0.10 ± 0.004 |
| 5e (2.5 mg per kg per day) | 62.4 | 0.11 ± 0.007 |
| 5e (5 mg per kg per day) | 78.0 | 0.08 ± 0.002* |
| DOX (2 mg per kg per day) | 84.6 | 0.06 ± 0.008* |