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. 2022 Jan 12;73(7):1894–1909. doi: 10.1093/jxb/erab549

Table 1.

Overview of the HSP70 family in the model plant Arabidopsis

UniProt Protein names AGI SUBA/UniProt (∗) detected in extracellular space Mutant phenotype No. of gene models High-impact mutations in 1001 genomes database
P22953 HSP70-1 AT5G02500 Cytosol, nucleus∗ A: altered plant growth and development (1), disabled immune response (2, 3), enhanced tolerance to heat shock, hypersensitive to ABA, compromised in the induced stomatal closure (2), γ-ray hypersensitivity and tolerance to salt, cadmium, and arsenic (4)
B: did not reveal any difference in the resistance against pathogens Hyaloperonospora parasitica and Pseudomonas syringae pv tomato (3), more susceptible to P. syringae pv. Maculicola ΔhopI (5)
2 1 (SNPs)
Q9S7C0 HSP70-14 AT1G79930 Cytosol, nucleus B: indistinguishable from the wild type (6) 2 4 (SNPs)
Q9SAB1 HSP70-16 AT1G11660 Cytosol, nucleus B: failed flower opening, abnormal floral organ formation, impaired fertilization and seed setting (7), suppressed seed germination under cold stress conditions (8) 4 1 (SNPs)
P22954 HSP70-2 AT5G02490 Cytosol, nucleus B: did not reveal any difference in the resistance against pathogens Hyaloperonospora parasitica and Pseudomonas syringae pv tomato (3), more susceptible to P. syringae pv. Maculicola Δhop (5) 1 0
O65719 HSP70-3 AT3G09440 Cytosol, nucleus∗ B: did not reveal any difference in the resistance against pathogens Hyaloperonospora parasitica and Pseudomonas syringae pv tomato (3) 4 0
Q9LHA8 HSP70-4 AT3G12580 Cytosol, nucleus C: abnormal embryogenesis, defective seedlings with high levels of ROS–RNAi in an hsc70-1 mutant background (9) 1 0
Q9S9N1 HSP70-5 AT1G16030 Cytosol∗ B: delayed growth under normal conditions, reduced survival of both seeds and seedlings after severe heat treatments, decreased growth activity under water deficit (10) 1 0
Q9SKY8 HSP70-8 AT2G32120 Cytosol 2 11 (SNPs)
F4JMJ1 HSP70-17 AT4G16660 Endoplasmic reticulum 2 3 (SNPs)
Q9LKR3 HSP70-11 (BIP1) AT5G28540 Endoplasmic reticulum, nucleus∗ B: BIP1+BIP2 double mutation has an effect on the fusion of polar nuclei during female gametophyte development (11) 1 0
Q39043 HSP70-12 (BIP2) AT5G42020 endoplasmic reticulum, nucleus B: compromised secretion of PR1 (12), enhanced fungal colonization (13), BIP1+ IP2 double mutation has an effect on the fusion of polar nuclei during female gametophyte development (11) 3 0
Q8H1B3 HSP70-13 (BIP3) AT1G09080 Endoplasmic reticulum, nucleus B: BIP1+BIP2+BIP3 triple mutation is pollen lethal (14) 2 5 (SNPs), 1 (INS), 1 (DEL)
F4HQD4 HSP70-15 AT1G79920 Golgi, cytosol, nucleus B: severe growth retardation, impaired stomatal closure and accelerated wilting, enhanced tolerance to potyvirus infection (6) 4 0
Q9LDZ0 HSP70-10 AT5G09590 Mitochondrion∗ 1 0
Q8GUM2 HSP70-9 AT4G37910 Mitochondrion, cytosol∗ B: severe growth defects, abnormal mitochondria and alterations to respiration because of an inhibition of the cytochrome c oxidase (15) 2 0
Q9C7X7 HSP70-18 AT1G56410 Plastid, cytosol∗ 1 10 (SNPs), 7 (INS), 46 (DEL)
Q9STW6 HSP70-6 AT4G24280 Plastid∗ B: variegated cotyledons, malformed leaves, growth retardation, impaired root growth (16), hsp70-6/hsp70-7 double mutants are lethal (17) 1 0
Q9LTX9 HSP70-7 AT5G49910 Plastid B: hsp70-6/hsp70-7 double-mutants are lethal (17), defective protein import into chloroplasts during early developmental stages (18) 1 1 (SNPs)

Based on UniProt (Bateman et al., 2017), SUBA 4.0 (Hooper et al., 2017), the 1001 genome database (Weigel and Mott, 2009), and the previously reported response of HSP70 overexpression (A), loss-of-function mutation (B), and RNAi (C): 1, Sung and Guy (2003); 2, Clément et al. (2011); 3, Noël et al. (2007); 4, Cazalé et al. (2009); 5, Jelenska et al. (2010); 6, Jungkunz et al. (2011); 7, Chen et al. (2019); 8 Ashraf et al. (2021); 9, Lee et al. (2009); 10, Kozeko (2021); 11, Maruyama et al. (2010); 12, Wang et al. (2005); 13, Qiang et al. (2012); 14, Maruyama et al. (2014); 15, Wei et al. (2019); 16, Su and Li (2008); 17, Latijnhouwers et al. (2010); 18, Su and Li (2010). SNP, single nucleotide polymorphism; INS, insertion; DEL, deletion.