Table 3.

Multivariate analysis of overall survival with Cox proportional hazard model stratified by stage at diagnosis.

	Stages I-II				Stage III
	HR	95% CI		P-value	HR	95% CI		P-value
Age, years
65-74 versus <65	1.39	1.13	1.70	.002	1.20	1.01	1.43	.040
75+ versus <65	1.72	1.40	2.11	<.001	1.59	1.34	1.89	<.001
Sex
Female versus male	0.91	0.77	1.07	.246	0.91	0.79	1.05	.176
Race
Other versus white	1.09	0.87	1.37	.446	1.02	0.85	1.22	.837
Diagnosis year
2013-2016 versus 2004-2008	0.93	0.77	1.12	.422	0.95	0.80	1.11	.498
2009-2012 versus 2004-2008	0.70	0.57	0.87	.001	0.81	0.68	0.96	.015
Primary site
Anus versus colon	1.65	1.07	2.55	.025	2.11	1.50	2.97	<.001
Esophagus versus colon	1.65	1.19	2.28	.002	1.67	1.25	2.23	.001
Gallbladder versus colon	3.23	2.17	4.82	<.001	1.53	0.99	2.37	.054
Pancreas versus colon	1.75	1.35	2.27	<.001	1.60	1.17	2.20	.003
Rectum versus colon	1.48	1.07	2.06	.017	1.53	1.22	1.92	<.001
Gastric versus colon	1.28	0.92	1.76	.139	1.39	1.10	1.76	.007
Morphology
Large cell and others versus small cell	1.19	0.98	1.46	.086	1.04	0.88	1.24	.654
Charlson Comorbidity
1 versus none	1.01	0.82	1.25	.944	1.21	1.03	1.44	.025
2+ versus none	1.63	1.24	2.13	.001	1.35	1.07	1.71	.013
Surgery
Yes versus no	0.37	0.30	0.45	<.001	0.60	0.49	0.73	<.001
Radiation
Yes versus no	0.74	0.59	0.91	.005	0.70	0.57	0.85	<.001
Chemotherapy
Yes versus no	0.89	0.73	1.08	.230	0.64	0.54	0.75	<.001