Table 5.
Multivariate analysis of overall survival with Cox proportional hazard model stratified by stage in patients receiving chemotherapy and radiation.
| Stages I–II (N = 302) | Stage III (N = 417) | |||||||
|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | P-value | HR | 95% CI | P-value | |||
| Age, years | ||||||||
| 65-74 versus <65 | 1.28 | 0.88 | 1.88 | .196 | 1.08 | 0.81 | 1.44 | .612 |
| 75+ versus <65 | 1.32 | 0.86 | 2.02 | .209 | 1.12 | 0.79 | 1.58 | .534 |
| Sex | ||||||||
| Female versus male | 1.07 | 0.78 | 1.48 | .665 | 0.98 | 0.76 | 1.26 | .862 |
| Race | ||||||||
| Other versus white | 0.99 | 0.64 | 1.51 | .951 | 1.05 | 0.75 | 1.47 | .783 |
| Diagnosis year | ||||||||
| 2013-2016 versus 2004-2008 | 0.79 | 0.56 | 1.12 | .181 | 0.91 | 0.69 | 1.21 | .529 |
| 2009-2012 versus 2004-2008 | 0.74 | 0.49 | 1.10 | .130 | 0.87 | 0.65 | 1.18 | .368 |
| Site | ||||||||
| Anus versus colon | 1.81 | 0.52 | 6.27 | .348 | 1.24 | 0.62 | 2.51 | .543 |
| Esophagus versus colon | 2.20 | 0.67 | 7.21 | .195 | 0.88 | 0.45 | 1.74 | .713 |
| Gallbladder versus colon | 1.61 | 0.41 | 6.25 | .496 | 0.42 | 0.14 | 1.26 | .120 |
| Pancreas versus colon | 2.28 | 0.69 | 7.55 | .176 | 1.06 | 0.46 | 2.46 | .887 |
| Rectum versus colon | 1.24 | 0.38 | 4.10 | .724 | 0.70 | 0.37 | 1.35 | .286 |
| Gastric versus colon | 1.57 | 0.44 | 5.58 | .485 | 0.63 | 0.31 | 1.26 | .190 |
| Morphology | ||||||||
| Large cell and others versus small cell | 1.13 | 0.81 | 1.57 | .476 | 1.34 | 1.04 | 1.74 | .027 |
| Charlson Comorbidity | ||||||||
| 1 versus none | 0.99 | 0.65 | 1.50 | .949 | 1.40 | 1.02 | 1.93 | .035 |
| 2+ versus none | 1.44 | 0.81 | 2.57 | .215 | 1.53 | 0.92 | 2.53 | .100 |
| Surgery | ||||||||
| Yes versus no | 0.63 | 0.44 | 0.91 | .012 | 0.77 | 0.59 | 1.01 | .058 |