Table 1.
Gene mutations overrepresented in TP53WT GEAs.
| Gene | TP53MUT (%) | TP53WT (%) | −log10(P-value) |
|---|---|---|---|
| MDM2 | 1.2 | 14.1 | 56.2 |
| ARID1A | 13.4 | 25.2 | 17.8 |
| CDK4 | 0.4 | 3.9 | 14.4 |
| PIK3CA | 7.9 | 16.2 | 13.3 |
| ERBB3 | 2.1 | 7 | 12.5 |
| ATM | 1.7 | 6 | 11 |
| CDH1 | 8.8 | 16 | 10 |
| BAP1 | 0.7 | 3.6 | 9.5 |
| TGFBR2 | 0.6 | 2.9 | 7.5 |
| GNAS | 4.5 | 8.8 | 6.5 |
| CTNNB1 | 2.8 | 6.1 | 5.5 |
| MAP2K1 | 0.8 | 2.7 | 5.4 |
| RNF43 | 3 | 6.3 | 5.2 |
| SOX9 | 1.5 | 3.8 | 5.1 |
| MLL2 | 4.4 | 7.6 | 4 |
| BCOR | 1.1 | 3 | 4 |
| ACVR1B | 0.3 | 1.4 | 3.5 |
| PTPN11 | 0.5 | 1.7 | 3.4 |
| MED12 | 0.1 | 0.8 | 3.2 |
| CHEK2 | 0.3 | 1.2 | 2.5 |
| NF1 | 2.2 | 3.8 | 2.4 |
| CTCF | 0.5 | 1.5 | 2.4 |
| MSH3 | 1.4 | 2.7 | 2.3 |
| MAP3K1 | 0.5 | 1.4 | 2.3 |
| CDKN2B | 9 | 11.9 | 2.2 |
| MLH1 | 0.8 | 1.8 | 2.1 |
| TBX3 | 0.1 | 0.5 | 2 |