TABLE 2.
Microbial taxa associated with gastric cancer risk in the meta-analyses
| Meta-analyses |
Asians (SWMHS) |
African Americans (SCCS) |
European Americans (SCCS) |
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|---|---|---|---|---|---|---|---|---|
| Taxa | OR (95% CI)a | P a | OR (95% CI)b | P b | OR (95% CI)b | P b | OR (95% CI)b | P b |
| Phylum Proteobacteria | ||||||||
| Betaproteobacteria (C) | 1.31 (1.03-1.67) | .03 | 1.22 (0.90-1.65) | .19 | 1.16 (0.67-2.00) | .59 | 2.29 (1.13-4.67) | .02 |
| Neisseriales (O) | 1.30 (1.03-1.65) | .03 | 1.17 (0.87-1.56) | .30 | 1.22 (0.72-2.05) | .46 | 2.32 (1.13-4.75) | .02 |
| Neisseriaceae (F) | 1.28 (1.01-1.62) | .04 | 1.14 (0.85-1.53) | .39 | 1.29 (0.76-2.18) | .35 | 2.31 (1.13-4.72) | .02 |
| Neisseria mucosa (S) | 1.31 (1.03-1.67) | .03 | 1.34 (0.99-1.81) | .06 | 1.24 (0.68-2.24) | .48 | 1.63 (0.72-3.68) | .24 |
|
| ||||||||
| Phylum Bacteroidetes | ||||||||
| Prevotella pleuritidis (S) | 1.26 (1.00-1.57) | .05 | 1.30 (0.99-1.69) | .06 | 1.15 (0.66-1.99) | .62 | 1.87 (0.79-4.42) | .15 |
|
| ||||||||
| Phylum Tenericutes | 0.70 (0.55-0.88) | 2.98 × 10−3 | 0.58 (0.42-0.81) | 1.24 × 10−3 | 1.37 (0.79-2.37) | .26 | 1.16 (0.64-2.09) | .63 |
| Mycoplasma orale (S) | 0.74 (0.59-0.94) | .01 | 0.66 (0.49-0.89) | 7.18 × 10−3 | 0.96 (0.57-1.63) | .89 | 1.04 (0.52-2.06) | .92 |
|
| ||||||||
| Phylum Firmicutes | ||||||||
| Eubacterium yurii (S) | 0.80 (0.65-0.98) | .03 | 0.73 (0.57-0.93) | 9.69 × 10−3 | 0.63 (0.31-1.27) | .20 | 1.77 (0.89-3.52) | .10 |
|
| ||||||||
| Phylum Actinobacteria | ||||||||
| Cutibacterium (G) | 0.77 (0.62-0.96) | .02 | 0.87 (0.67-1.12) | .29 | 0.58 (0.32-1.07) | .08 | 0.65 (0.33-1.29) | .22 |
Abbreviations: C, class; CI, confidence interval; F, family; G, genus; O, order; OR, odds ratio; S, species .
a
ORs and 95% CIs per SD increase in centered log-ratio (clr)-transformed absolute abundance of taxa and P values were derived from meta-analyses.
b
ORs and 95% CIs per SD increase in clr-transformed absolute abundance of taxa and P values were calculated from conditional logistic regression models, additionally adjusting for age, education, pack-years of smoking, drinking status, hypertension status and type 2 diabetes (T2D) status.