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. 2021 Aug 4;4(3):155–167. doi: 10.1093/pcmedi/pbab020

Figure 4.

Figure 4.

The antitumor activity of CXCL13 was mediated by both innate immunity and adaptive immunity. (A) BALB/cA-nu nude mice were injected in the right dorsal flank with 2 × 105 4T1, 4T1-pCDH, 4T1-CXCL13-1, or 4T1-CXCL13-2 cells. Bars, means ± SD (n = 10). (B) In BALB/c and BALB/cA-nu experiments, the ratios of average tumor volume between 4T1-CXCL13 and 4T1 groups were shown on day 32 after tumor inoculation, respectively (***P < 0.001). (C) 4T1 tumor growth in the bilateral tumor inoculation of BALB/c mice. Each curve stands for the 4T1 tumor growth of one mouse (n = 8). (D) Statistic results of 4T1 tumor volume on days 13, 22, and 31 after bilateral tumor inoculations (*P < 0.05, **P < 0.01).