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. 2022 Feb 18;23(4):e53684. doi: 10.15252/embr.202153684

Figure 7. Comparison of transcription between Ssrp1fl / fl ; CreERT2 +/+ MSCs treated with vehicle or 4‐OHT.

Figure 7

  • A
    EU incorporation measured by flow cytometry. Histograms of EU fluorescent signals from two biological replicates for each condition (except no EU).
  • B
    SSRP1 staining of the cells in A.
  • C
    Volcano plot of changes in transcript counts in 4‐OHT‐treated cells versus control. Red dots indicate transcripts with fold‐change ≥ 2 and FDR < 0.05. n = 2 biological replicates.
  • D
    MA plot showing the difference between the changes in transcript counts in 4‐OHT‐treated MSCs vs. control and the average expression of the same transcripts between conditions (baseMean). n = 2 cell cultures.
  • E, F
    Dot plots with the results of GO enrichment for genes upregulated (C) and downregulated (D) upon FACT depletion.