Table 2.

Uni- and multivariate analyses of MTR, TSR, and other clinicopathological variables.

	Univariate analysis				Multivariate analysis
	Training cohort		Validation cohort		Training cohort		Validation cohort
	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P
Age	1.03 (1.01–1.04)	<0.001	1.01 (0.99–1.03)	0.184	1.02 (1.01–1.04)	<0.001	1.02 (1.00–1.04)	0.049
Sex
Male	1
Female	0.84 (0.60–1.18)	0.317	1.44 (0.90–2.28)	0.125
Stage
II	1		1		1		1
III	2.67 (1.85–3.84)	<0.001	3.10 (1.80–5.35)	<0.001	2.73 (1.90–3.94)	<0.001	3.04 (1.76–5.25)	<0.001
Tumor site
Colon	1		1
Rectum	1.07 (0.77–1.48)	0.704	1.12 (0.71–1.78)	0.625
TSR
Stroma-low	1		1		1		1
Stroma-high	1.72 (1.23–2.41)	0.001	2.17 (1.32–3.57)	0.002	1.62 (1.14–2.32)	0.008	1.99 (1.20–3.28)	0.007
MTR
Mucus-low	1		1		1		1
Mucus-high	1.88 (1.18–2.99)	0.008	2.09 (1.21–3.60)	0.008	1.65 (1.01–2.71)	0.047	1.96 (1.12–3.42)	0.018

Abbreviations: HR, hazard ratio; CI, confidence interval; TSR, tumor-stroma ratio; MTR, mucus-tumor ratio.