Table 1.

Three different types of hepatic hemangiomas.

Parameter	Congenital hepatic hemangioma	Multifocal infantile hepatic hemangioma	Diffuse infantile hepatic hemangioma
Age at onset	Prenatal	Postnatal	Postnatal
Growth pattens	Grow antenatally and fully formed at birth	Growth in the first weeks or months after birth	Rapid growth in the first weeks or months after birth
Symptoms and complications	Rarely associated with cutaneous IH. Most cases are asymptomatic. Some cases have mild anemia or thrombocytopenia. Few cases with high-output cardiac failure due to macrovascular shunting. Do not cause hypothyroidism	Frequently associated with cutaneous IH. Many cases are asymptomatic. Some cases with moderate hypothyroidism, high-output cardiac failure secondary to macrovascular shunting	Frequently associated with cutaneous IH. Almost all cases are symptomatic, with abdominal compartment syndrome, cardiac failure, and severe hypothyroidism
Image findings on MRI	A solitary, well-defined, spherical lesion; usually hypointense to liver on T1-weight image and hyperintense on T2-weight image; centripetal enhancement with gadolinium	Multiple homogeneous enhanced spherical lesions with intervening areas of normal hepatic parenchyma; hypointense to liver on T1-weight image and hyperintense on T2-weight image	Innumerable lesions nearly involve the whole liver
Pathological features	Negative for glucose transporter-1	Positive for glucose transporter-1	Positive for glucose transporter-1
Management	Observation for asymptomatic patients; embolization or surgery for severe macrovascular shunting	Observation for asymptomatic patients; embolization or surgery for severe macrovascular shunting; propranolol, steroid, a combination of medical treatment; thyroid hormone replacement for cases with hypothyroidism; liver transplantation	Propranolol, steroid, or a combination of medical treatment; thyroid hormone replacement for cases with hypothyroidism; embolization for sever macrovascular shunting; liver transplantation