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Diagram depicting the mechanism of cancer-induced muscle atrophy by releasing ncRNAs. CC is associated with muscle wasting induced by the release of EVs. DNA is transcribed into ncRNAs, including miRNAs, lncRNAs, and circRNAs, which in turn regulate transcription and translation. Following the biogenesis, release, and uptake of EVs, ncRNAs are transferred into muscle cells and induce muscle wasting through ERS transfer.
