. 2021 Apr 23;4(2):136–147. doi: 10.1093/pcmedi/pbab008

Table 2.

ncRNAs mentioned above and their targets in skeletal muscle wasting induced by CC.

Organism (reference)	ncRNA	Expression	Target(s)	Function
Pancreatic ductal adenocarcinoma^78,79	miR-206	upregulated	Pax3/7, YY1, EIF4E3	activation of quiescent satellite cells
			MyoD, Twist-1	myoblast proliferation and differentiation
			CX43, Fstl1, Utrn	maturation of skeletal muscle
Pancreatic and colorectal cancer³⁷	miR-3184-3p/miR-1296-5p	upregulated	Wnt/β-catenin signaling, BMPR1B, GREM1, TGF-β	myoblast proliferation and differentiation
Pancreatic and colorectal cancer³⁷	miR-345-5p	upregulated	NOV, COL1A1, CYR61	activation of UPS and ALS
Pancreatic and colorectal cancer³⁷	miR-423-3p	upregulated	Cox6a2	ATP regulation and myogenic differentiation
Breast cancer⁸⁰	miR-147-3p	upregulated	Akt/mTOR	protein anabolism
Liver cancer⁸¹	lncMyoD	downregulated	IMP2-Mediated mRNA	myoblast proliferation and differentiation
Liver cancer^81,82	lncDum	downregulated	Dppa2	myoblast proliferation and differentiation
Location undetermined⁸³	lncCAA1/miR-330	downregulated	HuR/STAT3	myoblast differentiation
Colon carcinoma⁵³	miR-15	downregulated	IRS1, IGF1/PI3K/AKT signal	myogenesis and atrophy
Colon carcinoma^53,84	lncIRS1	upregulated	miR-15, Atrogin-1, MuRF1	myogenesis and atrophy