TABLE 3.
Gene set enrichment analysis (GSEA). Positive median changes imply increased biological process regulation, whereas negative median changes indicate decreased biological process regulation in cells treated with EGCG+HC vs vehicle control cells.
| Gene Significant Enrichment Analysis (GSEA) | 1321N1 (no. entities) | 1321N1 Median Change | 1321N1 p-value | LN18 (no. entities) | LN18 Median Change | LN18 p-value |
|---|---|---|---|---|---|---|
| endoplasmic reticulum unfolded protein response | 80 | 125.41 | 0.00E+00 | 81 | 127.65 | 0.00E+00 |
| inflammatory response | 253 | 104.68 | 9.00E-04 | n/a | n/a | n/a |
| activation of signaling protein activity involved in unfolded protein response | 62 | 103.14 | 5.00E-04 | 63 | 105.67 | 0.00E+00 |
| immune response | 252 | 102.46 | 1.40E-03 | n/a | n/a | n/a |
| intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | 25 | 102.11 | 6.00E-04 | 25 | 65.48 | 1.20E-03 |
| cellular metabolic process | 132 | −47.04 | 0.00E+00 | 843 | −123.598 | 0 |
| axon guidance | 316 | −28.946 | 0 | 320 | −77.104 | 0 |
| mitotic cell cycle | 387 | −108.81 | 0.00E+00 | 388 | −225.07 | 0.00E+00 |
| telomere maintenance | 54 | −53.25 | 0.00E+00 | 54 | −94.39 | 0.00E+00 |
| cell division/cytokinesis | 88 | −51.06 | 0.00E+00 | 52 | −86.52 | 0.00E+00 |
| DNA repair | 270 | −49.21 | 0.00E+00 | 270 | −154.39 | 0.00E+00 |