TABLE 4.
Fisher exact test (FET) analysis on gene dataset of p < 0.05, FDR.
| Biological process/signalling pathway | 1321N1 No. of overlapping entities | 1321N1 p-value | LN18 o. of overlapping entities | LN18 p-value |
|---|---|---|---|---|
| positive regulation of apoptotic process/apoptotic process | 50 | 2.95E-10 | 137 | 5.68902E-14 |
| axon guidance | 57 | 3.20E-10 | 60 | 4.47362E-08 |
| cell cycle arrest | 29 | 1.31E-07 | 33 | 1.07385E-07 |
| cellular protein metabolic process | 78 | 4.30E-16 | 119 | 2.15597E-33 |
| endoplasmic reticulum unfolded protein response | 23 | 8.59E-09 | 32 | 1.24068E-13 |
| mitotic cell cycle | 91 | 4.1441E-31 | 128 | 7.19555E-52 |
| mRNA metabolic process | 48 | 5.29E-12 | 90 | 5.3289E-37 |
| mRNA splicing, via spliceosome | 47 | 5.10E-16 | 64 | 1.57876E-24 |
| negative regulation of cell growth | 34 | 7.11E-11 | 22 | 0.003878426 |
| nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | 26 | 4.4963E-07 | 58 | 7.18064E-29 |
| response to DNA damage stimulus | 46 | 8.6222E-05 | 78 | 6.22536E-14 |
| response to drug | 71 | 1.36E-08 | 76 | 1.41321E-06 |
| small molecule metabolic process | 155 | 1.46E-11 | 202 | 2.82555E-17 |
| SRP-dependent co-translational protein targeting to membrane | 20 | 6.1778E-05 | 58 | 4.58081E-33 |
| Actin Cytoskeleton Regulation | 86 | 2.78E-03 | 100 | 0.013074903 |
| Focal Adhesion Regulation | 50 | 2.94E-02 | n/a | n/a |
| Hedgehog Pathway | 92 | 1.24E-02 | 120 | 0.001067468 |
| Insulin Action | n/a | n/a | 199 | 2.90484E-10 |
| Notch Pathway | n/a | n/a | 248 | 0.010106517 |