Figure 4. The density of meningeal CD3⁺ T cells and CD20⁺ B cells but not IBA1⁺ myeloid cells correlates with subcortical white matter lesion activity.

Spearman’s correlation coefficient between meningeal CD3⁺ T cell, CD20⁺ B cell, and IBA1⁺ myeloid cell count with proportion of active white matter lesions (WMLs) (A–C), proportion of mixed active/inactive WMLs (D–F), proportion of inactive WMLs (G–I), and proportion of remyelinated WMLs (J–L) in each of 27 MS donors. Each data point represents the proportion of WMLs obtained from all tissue blocks analyzed per case (range 5–72 blocks, median: 30 blocks per donor) and the mean meningeal cell count in all fields analyzed per case.