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. 2022 Mar 8;7(5):e155260. doi: 10.1172/jci.insight.155260

Figure 8. PKM2 and its enzymatic activity in regulation of mitochondrial function and glycolysis in podocyte.

Figure 8

(A and B) Representative curve and quantitated data of OCR in pEmpty (n = 5), pPKMKD (n = 6), pPKMKD + phPKM1 (n = 6), pPKMKD + phPKM2 (n = 4), and pPKMKD + phPKM2(K270M) (n = 4) lines. **P < 0.01 versus pEmpty; ##P < 0.01 for each pair of the compared groups. (C and D) Representative curve and quantitated data of and ECAR in pEmpty (n = 5), pPKMKD (n = 5), pPKMKD + phPKM1 (n = 6), pPKMKD + phPKM2 (n = 6), and pPKMKD + phPKM2(K270M) (n = 4) lines. *P < 0.05 versus pEmpty; #P < 0.05, ##P < 0.01. (E and F) Representative curve and quantitated data of OCR in pEmpty (n = 5), phPKM1 (n = 6), phPKM2 (n = 6), and phPKM2(K270M) (n = 5) lines. **P < 0.01 versus pEmpty. (G and H) Representative curve and quantitated data of and ECAR in pEmpty (n = 5), phPKM1 (n = 6), phPKM2 (n = 6), and phPKM2(K270M) (n = 6) lines. *P < 0.05, **P < 0.01 versus pEmpty. Data are mean ± SD, 2-way ANOVA followed by correction for multiple comparison.