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. 2022 Mar 8;7(5):e149094. doi: 10.1172/jci.insight.149094

Figure 4. IgG anti-cardiolipin production in Sle1 TNF–/– mice is CD4 dependent.

Figure 4

(A) Percentage of CD19+ and CD4+ in total PBMCs from Sle1 TNF–/– mice after TACI-Ig or anti-CD4 treatment, Mann-Whitney nonparametric test, **P < 0.005. (B–D) Changes in titers of serum IgG anti-cardiolipin antibodies in untreated (B) and TACI-Ig– (C) and anti-CD4– (D) treated mice. Dotted line represents the mean value for 5 C57BL/6 mice >9 months old. Repeated measures ANOVA Kruskal-Wallis, *P < 0.05. (E and F) ELISPOT assay shows number of spleen cells secreting IgM (E) and IgG (F) and total Ig and anti-cardiolipin antibodies. ANOVA Kruskal-Wallis with Dunn’s multiple comparisons test, *P < 0.05, **P < 0.005.