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. 2022 Mar 29;2022:6702733. doi: 10.1155/2022/6702733

Table 4.

Effect of Urtica simensis extract on bodyweight and rectal temperature of P. berghei-infected mice in Peter's test.

Treatment group Temperature Weight
D0 D4 % change in T D0 D4 % change in Wt
CON 37.80 ± 0.15 33.86 ± 0.28 −10.40 ± 0.93b3 33.67 ± 0.49 28.55 ± 0.19 −15.21 ± 0.04b3
US100 mg/kg 37.89 ± 0.16 35.06 ± 0.40 −7.47 ± 1.19b2 33.19 ± 0.48 32.70 ± 0.55 −1.48 ± 1.40a2
US200 mg/kg 36.32 ± 0.38 33.92 ± 0.71 −6.58 ± 2.06b2 33.82 ± 0.31 34.40 ± 0.27 1.71 ± 0.88a3
US400 mg/kg 38.44 ± 0.24 37.22 ± 0.97 −3.19 ± 2.33a1 34.11 ± 0.21 35.67 ± 0.81 4.55 ± 2.02a3
CQ25 mg/kg 37.66 ± 0.14 38.26 ± 0.24 1.61 ± 0.75a3 34.23 ± 0.31 35.47 ± 0.53 3.65 ± 1.69a3
CON 37.7 ± 0.68 33.39 ± 1.28 −11.44 ± 4.55b2 34.31 ± 0.31 30.10 ± 1.08 −12.27 ± 3.83b3
CF100 mg/kg 37.23 ± 0.41 36.66 ± 0.79 −1.51 ± 1.68a1 33.56 ± 0.30 32.28 ± 0.66 −3.81 ± 1.67a1
CF200 mg/kg 37.24 ± 0.41 37.00 ± 0.54 −0.64 ± 0.98a1 33.57 ± 0.62 32.93 ± 0.88 −2.21 ± 2.72a1
CF400 mg/kg 37.08 ± 0.48 37.05 ± 0.53 −0.08 ± 1.29a1 33.11 ± 0.74 33.71 ± 0.36 1.92 ± 2.03a3
CQ25 mg/kg 37.61 ± 0.49 37.81 ± 0.36 0.53 ± 0.77a2 34.25 ± 0.31 35.29 ± 0.32 3.04 ± 0.77a3
CON 36.78 ± 0.24 32.90 ± 0.85 −10.54 ± 3.28b1 32.9 ± 0.76 30.78 ± 1.08 −6.44 ± 1.60b2
EF100 mg/kg 36.79 ± 0.40 32.06 ± 0.66 −12.79 ± 2.07b2 34.55 ± 0.40 35.59 ± 0.61 −3.01 ± 3.07
EF200 mg/kg 36.18 ± 0.47 32.13 ± 0.61 −11.19 ± 2.62b1 33.69 ± 0.55 29.8 ± 0.71 −11.55 ± 1.65b3
EF400 mg/kg 33.87 ± 0.99 32.21 ± 0.76 −4.90 ± 3.09 33.11 ± 0.67 30.34 ± 0.47 −8.34 ± 2.18b1
CQ25 mg/kg 37.08 ± 0.52 37.34 ± 0.43 0.70 ± 0.47a1 33.53 ± 0.80 34.03 ± 1.01 1.48 ± 1.34a1
DW10 ml/kg 36.78 ± 0.26 34.10 ± 0.93 −7.28 ± 3.08 32.87 ± 0.79 29.45 ± 1.50 −10.40 ± 6.60b3
AF100 mg/kg 36.74 ± 0.33 33.28 ± 0.83 −9.41 ± 1.94 33.96 ± 0.22 30.64 ± 0.53 −9.77 ± 1.74b2
AF200 mg/kg 36.14 ± 0.50 33.49 ± 0.98 −7.33 ± 2.91 33.64 ± 0.47 32.03 ± 0.40 −5.11 ± 2.05b1
AF400 mg/kg 35.60 ± 0.89 33.71 ± 0.82 −5.30 ± 2.12 33.53 ± 0.58 32.42 ± 0.63 −4.78 ± 3.04
CQ25 mg/kg 36.81 ± 0.33 38.67 ± 0.52 5.05 ± 1.20a3 34.17 ± 0.36 34.89 ± 0.54 2.03 ± 0.57a1

Data are expressed as mean ± SEM (n = 6). aCompared to negative control. bCompared to the standard. 1P < 0.05; 2P < 0.01; 3P < 0.001. CON, negative control, received vehicle (2% Tween 80 10 ml/kg); DW, negative control, received distilled water 10 ml/kg; US, crude extract of Urtica simensis; CF, chloroform fraction; EF, ethylacetate fraction; AF, aqueous fraction; CQ, chloroquine.