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. Author manuscript; available in PMC: 2022 Oct 1.
Published in final edited form as: J Immunol. 2022 Mar 18;208(7):1813–1827. doi: 10.4049/jimmunol.2100700

Figure 3. No Method for Calculating Neoantigen Hydrophobicity is Consistently Associated with Immunogenicity.

Figure 3.

Comparison of the distribution of hydrophobicity values for the TESLA consortium, Carreno, Strønen, and Ott datasets between immunogenic and non-immunogenic neoantigens. Hydrophobicity was calculated by three methods. The TESLA consortium method is calculated as the number of hydrophobic amino acids divided by the total number of amino acids. The method based on the Chowell et al. empirical data uses the same calculation scheme but considers both hydrophobicity and other chemical properties such as side chain bulkiness and polarity in ranking the neoantigens. The Łuksza et al. method considers the change of an amino acid at the anchor residues compared to the closest matched human peptide. *:p<0.05