Figure 6.

The Ox-ApoB peptide fragment immune intervention significantly inhibits the progression of atherosclerosis and reduces the area of the necrotic core in the plaque. (a, b) The inhibitory effect of Ox-ApoB fragments on atherosclerotic lesions in mice. The control group, the F-adjuvant group, and the immunization group are represented by aortic ORO staining images (a) and the percentage of the positive plaque area in the whole aorta (b). (c–f) Three representative images of the aortic valve annulus stained with ORO (100x) (c) and H&E (100x) (d). The statistical graph of the percentage of the plaque-positive area in the ORO staining in the aortic annulus (e) and the statistical graph of the percentage of the crystalline necrotic core area in the plaque in the H&E staining (f). Data are expressed as the mean ± SD. ^∗∗P < 0.01 vs. the control group.