TABLE 4.
Susceptibility of recombinant HXB2D to nucleoside analogues in MT-4 cells and CBMCs
| Cell | Virus | IC50 (μM)a
|
||
|---|---|---|---|---|
| (−)dOTFC | (+)dOTFC | 3TC | ||
| MT-4 | HXB2D | 4.8 ± 1.1 | 6.6 ± 0.9 | 0.30 ± 0.09 |
| HXB2D-184I | 18 ± 3.4 | 27 ± 4.1 | 97 ± 4.7 | |
| HXB2D-184V | 65 ± 15 | >100 | >200 | |
| CBMCs | HXB2D | 3.4 ± 0.2 | 4.25 ± 0.65 | 0.24 ± 0.08 |
| HXB2D-184I | 3.5 ± 0.6 | 4.5 ± 0.75 | 7.5 ± 0.35 | |
| HXB2D-184V | 10 ± 0.8 | 9.0 ± 0.8 | >200 | |
a
The results were determined on the basis of RT activity in culture fluids. Data are means ± standard deviations of three independent experiments.