TABLE 5.

Susceptibility of clinical HIV-1 isolates to nucleoside analogues in CBMCs

Drug	IC50 (μM)a
	Wild-type isolates		Isolates resistant to 3TC			Isolates resistant to AZT
	4242	4246	3887	3350	4205	1075	4170
(−)dOTFC	0.25	0.3	0.3	18	15	1.8	0.5
(+)dOTFC	0.4	0.4	4.0	4.5	>100	3.0	2.0
3TC	0.2	0.025	10	>100	>100	0.09	NDb
AZT	0.007	0.008	0.002	ND	0.007	0.65	0.25

^aResults were determined on the basis of RT activity in culture fluids. Data are averages of two independent experiments. 

^bND, not determined.