Table 3.

Top salient regions contributing to classification based on graph convolutional network.

Rank	MDD vs. HC		FEDN vs. HC		Recurrent vs. HC		FEDN vs. recurrent
	Brain Region	Network	Brain Region	Network	Brain Region	Network	Brain region	Network
1	R dorsal ACC	CON	L posterior insula	CON	R dorsal ACC	CON	L inferior temporal cortex	DMN
2	R VLPFC	FPN	L ACC	CON	L posterior insula	CON	R VMPFC	DMN
3	L IPL	FPN	R ventral frontal cortex	CON	R VLPFC	FPN	R IPS	FPN
4	L posterior insula	CON	L ventral anterior PFC	FPN	R inferior temporal cortex	DMN	L occipital cortex	DMN
5	L DLPFC	FPN	L thalamus	CON	R VMPFC	DMN	L anterior PFC	DMN
6	R VMPFC	DMN	R VLPFC	FPN	L PCC	DMN	L temporal cortex	SMN
7	L precuneus	DMN	L temporal cortex	SMN	L IPL	FPN	R dorsal ACC	CON
8	R fusiform	CON	R IPS	FPN	R angular gyrus	DMN	R posterior insula	SMN
9	R inferior temporal cortex	DMN	R middle insula	CON	R inferior cerebellum	CN	L parietal cortex	SMN
10	R lateral cerebellum	CN	L occipital cortex	ON	L occipital cortex	DMN	L posterior parietal cortex	FPN

Abbreviations: L, left; R, right; MDD, major depressive disorder; HC, healthy control; FEDN, first-episode drug-naïve; ACC, anterior cingulate cortex; VLPFC, ventrolateral prefrontal cortex; IPL, inferior parietal lobule; DLPFC, dorsolateral prefrontal cortex; VMPFC, ventromedial prefrontal cortex; IPS, intraparietal sulcus; PCC, posterior cingulate cortex; DMN, default mode network; CON, cingulo-opercular network; FPN, fronto-parietal network; SMN, sensorimotor network; ON, occipital network; CN, cerebellum network.