Table 3.

Clinicopathologic Factors Affecting Survival of Pathological T1 Cases (n = 302) Examined by Univariable and Multivariable Analyses Using Cox Proportional Hazards Model

Variable	Recurrence-Free Survival						Disease-Specific Survival
	Univariable			Multivariable			Univariable			Multivariable
	HR	95% CI	p-Value	HR	95% CI	p-Value	HR	95% CI	p-Value	HR	95% CI	p-Value
Sex (M/F)	0.825	0.424–1.604	0.571	0.850	0.417–1.735	0.656	0.495	0.208–1.177	0.111	0.366	0.136–0.988	<0.05
Age (<65, ≥65), y	0.931	0.479–1.806	0.832	0.725	0.358–1.468	0.372	0.710	0.299–1.687	0.438	0.491	0.186–1.297	0.151
Invasion size	2.021	1.241–3.289	<0.005	1.299	0.759–2.224	0.339	2.659	1.377–5.132	<0.01	2.075	0.933–4.617	0.074
Nodal metastasis	13.14	6.733–25.65	<0.00001	4.043	1.807–9.042	<0.001	13.870	5.832–32.97	<0.00001	5.783	1.982–16.88	<0.01
Lymphatic invasion	7.674	3.938–14.95	<0.00001	3.341	1.593–7.008	<0.01	7.103	2.998–16.83	<0.00001	2.670	0.983–7.254	0.054
Vascular invasion	6.010	2.988–12.09	<0.00001	1.893	0.860–4.163	0.113	4.737	1.963–11.43	<0.001	1.093	0.400–2.988	0.863
MP component (<5%, ≥5%)	3.185	1.560–6.505	<0.01	2.032	0.925–4.463	0.078	4.579	1.927–10.88	<0.001	1.937	0.703–5.34	0.201
Solid component (<5%, ≥5%)	4.001	2.034–7.872	<0.0001	2.371	1.098–5.117	<0.05	3.442	1.424–8.32	<0.01	3.147	1.078–9.185	<0.05

Note: Bold values denote statistical significance at the p < 0.05 level.

CI, confidence interval; F, female; HR, hazard ratio; M, male; MP, micropapillary.