Table 3.
Known Groups Validity for NSCLC-SAQ Total Score at Baseline
| Known Group Classification | n | LSmean (SE)a | 95% CI | p Value |
|---|---|---|---|---|
| PGIS-LC version 1.0 | <0.0001 | |||
| Not severe | 89 | 4.03 (0.36) | 3.31–4.74 | |
| Mildly severe | 100 | 5.48 (0.34) | 4.80–6.15 | |
| Moderately severe | 108 | 8.31 (0.33) | 7.66–8.95 | |
| Very severe/extremely severeb | 46 | 10.70 (0.50) | 9.70–11.69 | |
| PGIS-LC version 2.0 | ||||
| No symptoms | 38 | 4.43 (0.46) | 3.52–5.35 | <0.0001 |
| Mild | 66 | 5.83 (0.35) | 5.13–6.52 | |
| Moderate | 57 | 8.04 (0.38) | 7.29–8.78 | |
| Severe/very severeb | 31 | 12.06 (0.51) | 11.05–13.08 | |
| EORTC QLQ-C30 GHS/QoLc | ||||
| <58.8 | 209 | 9.39 (3.76) | 8.88–9.90 | <0.0001 |
| ≥58.8 | 326 | 5.25 (3.24) | 4.90–5.61 | |
| ECOG performance statusd | ||||
| 0 | 191 | 5.74 (3.87) | 5.19–6.29 | <0.0001 |
| 1 | 345 | 7.50 (3.93) | 7.09–7.92 |
CI, confidence interval; ECOG, Eastern Cooperative Oncology Group; EORTC QLQ-C30 GHS/QoL, European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire core 30 Global Health Status/Quality of Life scale; LSmean, least square mean; NSCLC-SAQ, NSCLC Symptom Assessment Questionnaire; PGIS-LC, patient global impression of severity–lung cancer symptoms.
LS means were calculated using ANOVA Welch F-test, with α = 0.05 level.
Categories were combined owing to low cell counts.
Population reference value for NSCLC from EORTC QLQ-C30 reference values.16
ECOG performance status 0 means normal activity (fully active, able to carry on all predisease performance without restriction) whereas 1 means with symptoms but ambulatory (restricted in physically strenuous activity, but ambulatory and able to carry out work of a light or sedentary nature [e.g., light housework, office work]).