Table 5.
irAEs by Sex for Patients With Lung Cancer From UH (2005–2020) Database
| Feature | UH |
||
|---|---|---|---|
| Male 1074 (51.1%) |
Female 1028 (48.9%) |
p Value | |
| irAEs, n (%)a | |||
| Yes | 472 (43.9) | 448 (43.6) | 0.89 |
| Subtypes of irAEs, n (%)a | |||
| Rash or eczema | 17 (1.6) | 16 (1.6) | 1 |
| Diarrhea | 28 (2.6) | 45 (4.4) | 0.03 |
| Adrenal insufficiency | 1 (0.1) | 2 (0.2) | 0.96 |
| Hyperlipidemia | 306 (28.5) | 244 (23.7) | 0.01 |
| Nephritis | 0 | 0 | — |
| Leukopenia | 15 (1.4) | 15 (1.5) | 1 |
| Hypothyroidism | 53 (4.9) | 101 (9.8) | <0.001 |
| Hyperthyroidism | 0 | 13 (1.3%) | <0.001 |
| Hypophysitis | 25 (2.3) | 27 (2.6) | 0.76 |
| Parathyroidism | 3 (0.3) | 7 (0.7) | 0.30 |
| Acute kidney injury | 68 (6.3) | 39 (3.8) | 0.01 |
| Neuritis | 21 (2) | 23 (2.2) | 0.76 |
| Hepatitis | 11 (1) | 5 (0.5) | 0.24 |
| Colitis | 11 (1) | 9 (0.9) | 0.89 |
| Pancreatitis | 5 (0.5) | 8 (0.8) | 0.52 |
| Mucositis | 7 (0.7) | 4 (0.4) | 0.59 |
| Arrhythmia | 184 (17.1) | 112 (10.9) | <0.001 |
| Myocardial infarction | 25 (2.3) | 12 (1.2) | 0.06 |
| Myocarditis | 55 (5.1) | 35 (3.4) | 0.06 |
| Pericarditis | 20 (1.9) | 13 (1.3) | 0.35 |
| Cardiomyopathy | 33 (3.1) | 12 (1.2) | 0.004 |
| Pneumonitis | 116 (10.8) | 100 (9.7) | 0.46 |
| Meningitis | 0 | 0 | — |
| Encephalopathy | 4 (0.4) | 2 (0.2) | 0.72 |
| Vitiligo | 1 (0.1) | 1 (0.1) | 1 |
| Thrombocytopenia | 22 (2) | 18 (1.8) | 0.73 |
| DM1 | 4 (0.4) | 7 (0.7) | 0.49 |
DM1, diabetes mellitus type 1; irAE, immune-related adverse event; UH, University Hospital.
a
Compared with Pearson’s chi-square test.