Figure 3.

Naproxen treatment inhibited the growth of MC38 in vivo and increased the influx of activated Tbet+ tumor infiltrating lymphocytes. (A) Tumor volume of mice treated with control diet (●) or diet containing 400 ppm Naproxen (■); n=10 mice/group; ****p<0.0001. Percent of infiltrating (B) CD45⁺CD3-PD-L1⁺ (C) CD45⁻PD-L1⁺, (D) Tbet⁺CD4⁺ (E) Tbet⁺CD8⁺, (F) Ki67⁺CD4⁺, (G) Ki67⁺CD8⁺, (H) LAG3⁺CD8⁺ (I) CD4⁺FOXP3⁺PD-1⁺LAG3⁺ and (J) F480⁺CD11b⁺ for the indicated treatment group presented as box and whisker plots, horizontal line at median and whiskers minimum to maximum, showing all points. *p<0.05; **p<0.01; ***p<0.001 n=6-10 mice/group.