Machine learning approaches for pose estimation and clustering of behaviors in mice. Top: Pose estimation algorithms, such as DeepLabCut, can track mouse body parts across time. Middle: Supervised machine learning approaches (e.g., SiMBA) can identify specific behaviors when classifiers are predefined. Bottom: Unsupervised machine learning algorithms (e.g., B-SOID, VAME) are used to identify different sets of behaviors in an unbiased manner.