Table 2.
Studies measuring negative affective behaviors during abstinence from alcohol vapor inhalation.
| Study | Model (duration) | Strain (sex) | Test (time into abstinence) | |
|---|---|---|---|---|
| Short-term exposure (7 d or less) | ||||
| 1 | Finn et al., 2000 | Continuous (3 d) | C57BL/6J & DBA/2J (M) | EPM (5–10 h) |
| 2 | Kliethermes et al., 2004 | Continuous (3 d) | WSC-2 (F+M) | EZM (1–2 d); LDB (10 h, 1 d, 36 h, 2 d) |
| 3 | Metten et al., 2018 | Continuous (3 d) | HS/Npt (F+M) | LDB (12 h, 1 d); EZM (1 d), SP (2 d) |
| 4 | Lowery-Gionta et al., 2015 | Intermittent (5 d) | DBA2/J (M) | SA (1 d, 7 d) |
| 5 | Hartmann et al., 2020 | Intermittent (1 wk) | C57BL/6J & /6NJ (F+M) | SP, LDB, FS (1 – 27 d) |
| 6 | Kash et al., 2009 | Intermittent (1 wk) | C57BL/6J (M) | EPM (4–6 h) |
| Intermediate exposure (8 d to 3 wk) | ||||
| 7 | Hartmann et al., 2019 | Intermittent (10 d) | WSP-2 & WSR-2 (F+M) | MB, LDB, SP (1 d - 7 wk) |
| 8 | McCool & Chappell, 2015 | Intermittent (2 wk) | C57BL/6J & DBA/2J (M) | LDB (3 d) |
| 9 | Bray et al., 2017 | Intermittent (3 wk) | C57BL/6J & CCL2-tg (F+M) | LDB (3 d); FST (7 d) |
| Chronic exposure (4+ wk) | ||||
| 10 | Daut et al., 2015 | Intermittent (4 wk) | C57BL/6J (F+M) | LDB (2 d) |
| 11 | Holmes et al., 2012 | Intermittent (4 wk) | C57BL/6J (M) | LDB (2 d) |
| 12 | Jury et al., 2017 | Intermittent (4 wk) | C57BL/6J (F+M) | NSF (3 d); MB (6 d) |
| 13 | Maldonado-Devincci et al., 2016 | Intermittent (4 wk) | C57BL/6J (M) | FS (8 h); FS (3 d) |
| 14 | Pleil et al., 2015 | Intermittent (4 wk) | C57BL/6J (M) | MB (2 d) |
| 15 | Sidhu et al., 2018 | Intermittent (4 –6 wk) | C57BL/6J & DBA/2J (M) | NSF (5 d); BB (3–7 d); SA (6–7 d); MB (10 d) |
| 16 | Warden, et al., 2020 | Intermittent (4 wk) | C57BL/6J (M) | NSF (5 d) |
| 17 | Rose et al., 2016 | Intermittent (5 wk) | C57BL/6J (M) | MB (3 d) |
| 18 | Kimbrough et al., 2020 | Intermittent (6 wk) | C57BL/6J (M) | BB (7 d); MB (10 d) |
| 19 | Starski et al. 2020 | Intermittent ’binge” (4 h/d; 6–9 wk) | C57BL/6J (M) | OF (20 d), SP (1–3 wk) |
Bold font indicates an alcohol-induced change in behavior. Study numbers are identified in Figure 1. BB, bottle-brush; EPM/EZM, elevated plus maze/elevated zero maze; FS, forced swim; LDB, light-dark box; MB, marble burying; NO, novel object encounter; NSF, novelty-suppressed feeding; OF, open field; SA, social approach; SP, sucrose/saccharin preference. M, male; F, female.