Table 3.
Negative affective behaviors that emerge during abstinence from voluntary alcohol drinking in mice.
| Study | Model (duration) | Strain (sex) | Test (time into abstinence) | |
|---|---|---|---|---|
| Continuous alcohol drinking | ||||
| 1 | Pang et al., 2013a | 2BC (24 h/d; 6 wk) | C57BL/6J (F) | SP, EPM (14 d); LDB, NSF (17 d); FS (19 d) |
| 2 | Pang et al., 2013b | 2BC (24 h/d; 6 wk) | C57BL/6J (F) | SP (15 d); FS (17 d) |
| 3 | Stevenson et al., 2009 | 2BC (24 h/d; 4 wk) | C57BL/6J (M) | FS, OF (1 d, 14 d) |
| 4 | Holleran et al., 2016 | 2BC (24 h/d; 6 wk) | C57BL/6J (F) | FS (1 d, 18 d); EPM (14 d); NSF (15 d, 35 d) |
| 5 | Vranjkovic et al., 2018 | 2BC (24 h/d; 6 wk) | C57BL/6J (F) | EPM (1 d, 7 d); NSF (14 d); FS (21 d) |
| 6 | Gong et al., 2017 | 2/3BC (24 h/d; 3–6 wk) | C57BL/6J (M) | OF, LDB (12 h); EPM (1 d), FS (13 d), TS (14 d) |
| 7 | Centanni et al., 2019 | 2BC (24 h/d; 6 wk) | C57BL/6J (F+M) | NSF (15 d); FS (21 d) |
| 8 | van Rijn et al., 2010 | 2BC (4 h/d; 5d) | C57BL/6J (M) | EPM, LDB (24 h) |
| 9 | Dao et al., 2020 | 2BC (24 h/d; 6 wk) | C57BL/6J (F+M) | EPM (7 d); OF (14 d); SP (21 d); FS (28 d) |
| Intermittent drinking | ||||
| 10 | Bloch et al., 2020 | 2BC (3 d/wk; 7 wk) | C57BL/6J (F+M) | EZM (1d); NO (19–20 d); NSF (27–28 d) |
| 11 | Wang et al., 2021 | 2BC (3 d/wk; 3 wk) | C57BL/6J (M) | OF (12 h); EPM (12 h) |
| 12 | Hwa et al., 2015 | 2BC (3 d/wk; 1– 8 wk) | Swiss-Webster (M) | Agg, SA (6–8 h) |
| 13 | Quijano Carde et al 2022 | 2BC (3 d/wk; 10 wk) | C57BL/6J (F+M) | EPM, MB, OF (24 h) |
| Drinking-in-the-dark | ||||
| 14 | Lee et al., 2015 | DID (6 wk) | C57BL/6J (M) | SP, LDB, NO, FS, EPM, MB (1–2 d, 21–22 d) |
| 15 | Lee et al., 2016 | DID (14 d) | C57BL/6J (M) | NO, FS (1 d); MB (2 d) |
| 16 | Lee, Coehlo, Solton et al., 2017 | DID (14 d) | C57BL/6J (M) | MB, FS, SP (1 d); MB, FS, SP (28 d) |
| 17 | Olney et al., 2018 | DID (1, 3, 6 wk) | C57BL/6J (M) | FS (1 d); SP (1 wk) |
| 18 | Szumlinski et al., 2019 | DID (14 d) | C57BL/6J (F+M) | ACS, NO, FS, LDB, MB (1–2 d, 30–31 d) |
| 19 | Bloodgood et al., 2020 | DID (4 wk) | OPRK1/Pdyn KO mice (F+M) | EPM (8 h) |
| 20 | Belmer et al., 2018 | DID (12–14 wk) | C57BL/6J (M) | EPM, MB, OF (24 h) |
| 21 | Rath 2020 | DID (8–19 wk) | C57BL/6J (F+M) | EPM, LDB, MB (36 h) |
| 22 | Cox et al., 2013 | DID (1, 3, 6, 10 wk) | C57BL/6J (M) | EPM, OF (1 d) |
| 23 | Flanigan et al., 2022 | DID (3 wk) | C57BL/6J (F+M) | SA, OF, ACS (7 d) |
Bold font indicates an alcohol-induced change in behavior. Study numbers are identified in Figure 2. ACS, acoustic startle; Agg, aggression; BB, bottle-brush; EPM/EZM, elevated plus maze/elevated zero maze; FS, forced swim; L-D, light-dark box; MB, marble burying; NO, novel object encounter; NSF, novelty-suppressed feeding; OF, open field; SA, social approach; SP, sucrose/saccharin preference; TS, tail suspension; M, male; F, female; KO, knockout.