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. Author manuscript; available in PMC: 2023 May 1.
Published in final edited form as: Alcohol. 2022 Feb 15;100:41–56. doi: 10.1016/j.alcohol.2022.02.001

Table 4.

Influence of alcohol-stress interactions on affective phenotypes in mice.

Study Alcohol-Stress Model Strain (sex) Test (time into abstinence)
Rodberg et al., 2017 CIE + FS C57BL/6J (M) MB (3–5 d)
den Hartog et al., 2020 CIE + FS C57BL/6J (F+M) MB (4 d)
Padula et al., 2020 CIE + FS C57BL/6J (M) NSF, MB (12–13 d)
Nelson et al., 2018 i.g. EtOH + SDS C57BL/6J (M) SI (1 d)
Nennig et al., 2020 IA Drinking + SDS C57BL/6J (M) SI (1 d)
de Almeida Magalhaes et al., 2018 2BC + MS C57BL/6 (F+M) L-D (<1 d)
Okhuarobo et al., 2020 CIE + LBN C57BL/6J (F+M) EPM (10–11 d); Digging (13); Grooming (17 d); TS (19 d)

Bold font indicates a significant change in negative affective behavior. 2BC, two-bottle choice; IA, intermittent access; CIE, chronic intermittent ethanol; EPM, elevated plus maze; FS, forced swim; LBN, limited bedding and nesting; L-D, light-dark box; MB, marble burying; MS, maternal separation; NSF, novelty-suppressed feeding; SDS, social defeat stress; SI, social interaction; TS, tail suspension; M, male; F, female.