Table 2.
Characteristics of Patients with Breast Cancer and Received an Oncotype DX RS Test by Race/Ethnicity
| White | Black | Hispanic | Asian American | p | |
|---|---|---|---|---|---|
| n | 69125 | 6118 | 3391 | 3468 | |
|
| |||||
| Age (mean (SD)) | 58.5 (10.2) | 57.1 (10.4) | 55.2 (10.7) | 54.6 (10.7) | <0.001 |
| Age Group | <0.001 | ||||
| 18–34 | 0.9 | 1.4 | 1.6 | 2.0 | |
| 35–44 | 8.1 | 10.4 | 15.1 | 17.1 | |
| 45–54 | 26.8 | 28.1 | 32.1 | 32.3 | |
| 55–64 | 33.5 | 34.4 | 30.0 | 28.3 | |
| 65–74 | 25.6 | 21.4 | 17.1 | 17.6 | |
| >75 | 5.0 | 4.3 | 4.0 | 2.7 | |
| Year of Diagnosis | <0.001 | ||||
| 2010 | 13.6 | 13.4 | 12.3 | 13.0 | |
| 2011 | 17.8 | 17.5 | 17.2 | 16.1 | |
| 2012 | 20.3 | 19.2 | 19.2 | 19.1 | |
| 2013 | 23.1 | 24.5 | 23.4 | 24.8 | |
| 2014 | 25.3 | 25.5 | 27.8 | 27.0 | |
| ODX Risk Recurrence Score (Median [IQR]) | 16.0 [11.0, 21.0] | 16.0 [11.0, 23.0] | 16.0 [11.0, 21.0] | 16.0 [11.0, 22.0] | <0.001 |
| Traditional Risk Recurrence Score | <0.001 | ||||
| 0–17 | 59.8 | 55.0 | 59.2 | 58.5 | |
| 18–30 | 32.8 | 33.6 | 32.9 | 33.6 | |
| 31–100 | 7.5 | 11.4 | 7.9 | 7.9 | |
| TAILORx Risk Recurrence Score | |||||
| 0–10 | 23.4 | 22.0 | 23.0 | 23.0 | |
| 11–25 | 62.6 | 59.0 | 62.8 | 61.4 | |
| 25–100 | 14.0 | 19.1 | 14.2 | 15.6 | |
| Region | <0.001 | ||||
| Northeast | 25.0 | 21.0 | 26.0 | 26.0 | |
| Midwest | 28.4 | 19.9 | 10.3 | 13.1 | |
| South | 29.1 | 50.0 | 31.5 | 19.4 | |
| West | 14.8 | 4.6 | 26.6 | 34.8 | |
| Unknown | 2.7 | 4.4 | 5.6 | 6.7 | |
| Geographic Location | <0.001 | ||||
| Metro | 82.5 | 90.8 | 94.1 | 92.3 | |
| Urban | 13.4 | 6.6 | 3.6 | 4.2 | |
| Rural | 1.8 | 0.7 | 0.3 | 0.5 | |
| Unknown | 2.4 | 1.9 | 2.0 | 2.9 | |
| Income Quartile1 | <0.001 | ||||
| <$30000 | 8.3 | 30.2 | 16.7 | 5.4 | |
| $30000–$34999 | 17.3 | 21.1 | 20.9 | 10.1 | |
| $35000–$45999 | 26.7 | 22.9 | 27.6 | 21.0 | |
| >$46000 | 46.5 | 24.9 | 34.0 | 62.4 | |
| Unknown | 1.1 | 0.9 | 0.8 | 1.1 | |
| High School Education Quartile1 | <0.001 | ||||
| ≥29% | 7.9 | 25.7 | 34.9 | 12.0 | |
| 20%–28.9% | 18.9 | 33.6 | 23.3 | 16.6 | |
| 14%–19.9% | 31.9 | 23.7 | 21.3 | 27.8 | |
| <14% | 40.2 | 16.1 | 19.7 | 42.3 | |
| Unknown | 1.1 | 0.9 | 0.7 | 1.2 | |
| Facility Type | <0.001 | ||||
| Community | 8.9 | 6.0 | 7.1 | 8.2 | |
| Comprehensive Community | 48.1 | 38.7 | 37.3 | 39.3 | |
| Academic/Research Program | 31.9 | 39.6 | 39.2 | 43.2 | |
| Integrated Network | 11.1 | 15.8 | 16.4 | 9.3 | |
| Insurance | <0.001 | ||||
| No Insurance | 1.0 | 2.5 | 6.0 | 2.0 | |
| Private Insurance | 65.1 | 57.8 | 54.8 | 69.1 | |
| Government Insurance | 33.0 | 38.7 | 38.1 | 28.1 | |
| Unknown | 0.9 | 1.0 | 1.1 | 0.8 | |
| Tumor Size (median [IQR]) | 15.0 [11.0, 20.0] | 15.0 [11.0, 21.0] | 15.0 [11.0,21.0] | 15.0 [11.0, 21.0] | <0.001 |
| Tumor Size (mm) | <0.001 | ||||
| ≤10 | 24.4 | 21.8 | 21.8 | 21.9 | |
| 11–20 | 52.1 | 50.7 | 51.5 | 51.3 | |
| >20 | 23.0 | 26.8 | 25.9 | 26.2 | |
| Unknown | 0.5 | 0.7 | 0.7 | 0.6 | |
| Histologic Grade | <0.001 | ||||
| I | 31.0 | 25.8 | 26.5 | 24.7 | |
| II | 50.2 | 49.7 | 52.4 | 52.2 | |
| III | 13.4 | 19.1 | 15.3 | 15.4 | |
| Unknown | 5.2 | 5.4 | 5.8 | 7.6 | |
| Histologic Type | <0.001 | ||||
| Ductal | 73.6 | 71.8 | 73.8 | 76.3 | |
| Lobular | 12.2 | 11.6 | 10.6 | 7.5 | |
| Other | 14.2 | 16.5 | 15.7 | 16.3 | |
| PR Status | <0.001 | ||||
| Positive | 91.1 | 87.9 | 92.0 | 91.0 | |
| Negative | 8.8 | 12.0 | 7.8 | 8.9 | |
| Borderline | 0.05 | 0.05 | 0.1 | 0.03 | |
| Unknown | 0.02 | 0.00 | 0.1 | 0.1 | |
| Lymph Vascular Invasion | 0.003 | ||||
| Negative | 80.0 | 80.0 | 78.0 | 80.4 | |
| Positive | 9.7 | 9.4 | 11.1 | 10.7 | |
| Unknown | 10.2 | 10.6 | 10.9 | 9.0 | |
| Comorbidity | <0.001 | ||||
| No | 86.3 | 78.1 | 82.3 | 87.2 | |
| Yes | 11.7 | 18.0 | 14.6 | 11.4 | |
| Unknown | 2.0 | 3.9 | 3.1 | 1.5 | |
| Surgery | <0.001 | ||||
| Lumpectomy | 69.4 | 70.6 | 66.0 | 63.1 | |
| Mastectomy | 30.6 | 29.4 | 34.0 | 36.8 | |
| Radiation | <0.001 | ||||
| No | 30.7 | 29.7 | 33.8 | 36.2 | |
| Yes | 69.2 | 70.1 | 66.1 | 63.7 | |
| Unknown | 0.1 | 0.2 | 0.1 | 0.1 | |
| Chemotherapy | <0.001 | ||||
| No | 78.3 | 73.4 | 74.7 | 75.1 | |
| Yes | 20.3 | 24.9 | 23.3 | 23.0 | |
| Unknown | 1.4 | 1.6 | 2.0 | 1.8 | |
| Follow-up (median [IQR]) | 40.4 [27.8, 55.6] | 40.1 [27.9, 55.1] | 37.9 [25.5,53.0] | 38.5 [26.7, 54.1] | <0.001 |
1.
Median annual household income and educational attainment were estimated by matching patients’ zip codes against American Community Survey data from 2000 or 2012, depending on the time of diagnosis.