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. 2022 Apr 5;12:5664. doi: 10.1038/s41598-022-08422-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Reduced Plpp3 expression protects against abdominal aortic aneurysm development. (A) Plasma cholesterol at baseline and post-4 week AngII were measured in WT (n = 7) and Plpp3^+/− (n = 6) mice, *P < 0.001, Two-way ANOVA, Bonferroni t-test, all pairwise multiple comparison. (B) Abdominal aorta gene expression from WT (n = 6) and Plpp3^+/− (n = 6) following AngII treatment. (C) Representative images of aortas from WT and Plpp3^+/−. (D) Abdominal aortic diameter measurements of WT (n = 9) and Plpp3^+/− (n = 6) were measured using ultrasound at baseline and 4 week AngII,*P < 0.001, ^#P < 0.05, Two-way ANOVA, Holm-Sidak, all pairwise multiple comparison. (E) Percent incidence of AAA in WT (n = 9) and Plpp3^+/− (n = 6) mice treated with AngII for 4 weeks P = 0.068 by Fischer’s exact test.