Fig. 2. IL-37D transgene increases energy expenditure in HFD-fed mice.

Male IL-37Dtg and WT mice were fed on HFD or NCD (n = 4 per group). The energy expenditure (a, b), VCO₂ (c, d), and VO₂ (e, f) were measured in individual mouse using calorimetry system. Data represent mean ± SEM. ***p < 0.001, determined by two-way ANOVA (b, d, f).