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. 2022 Apr 5;8:18. doi: 10.1038/s41522-022-00283-2

Fig. 8. Paradigm summarizing the crosstalk between the gut microbiota and the host via the gut microbiota-blood-liver and fat axes in mediating host thermogenesis under cold stress.

Fig. 8

FFAR2, free fatty acid receptor 2; FFAR2, free fatty acid receptor 3; UCP3, uncoupling protein 3; GLP-1, glucagon-like peptide-1; PYY, peptide YY; SCFAs, short-chain fatty acids; TCA, taurocholic acid; GCA, sodium glycocholate hydrate; TLCA, taurolithocholic acid; TDCA, taurodeoxycholic acid; CDCA, chenodeoxycholic acid; GCDCA, glycochenodeoxycholic acid; CYP8B1, cytochrome P450, family 8, subfamily b, polypeptide 1; NR0B2, nuclear receptor subfamily 0, group B, member 2; FAS, fatty acid synthase; SLC2A8, solute carrier family 2 (facilitated glucose transporter) member 8; SLC2A12, solute carrier family 2 (facilitated glucose transporter) member 12; FXR, farnesoid X receptor; CLPS, colipase; CPT1B, carnitine palmitoyltransferase 1B. The elements, such as snowflake, sun, liver, and brain, were used from BioRender-biorender.com platform.