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. 2022 Apr 5;13:1825. doi: 10.1038/s41467-022-29416-z

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2022

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Fig. 3 — a Cryo-EM 2D class averages for N1-CA09-sNAp-155 showing fully closed tetramers (scale bar, 10 nm) (top left). Cryo-EM map, colored by individual head domain, viewed down the four-fold symmetry axis (top right) and an orthogonal view (bottom left). b The three major regions targeted for mutation: WT N1-CA09 (PDB 4B7Q, left), with residues targeted for mutation indicated (red). Space A (top), Space B (middle), and space D (bottom). Corresponding regions in the N1-CA09-sNAp-155 single-particle reconstruction (right), with mutated residues indicated (blue) and non-mutated residues involved in packing colored by chain as in panel a. The red sphere highlights the position of a cavity in space D.