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. 2022 Apr 5;5:310. doi: 10.1038/s42003-022-03266-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Relative mRNA expression of senescence-related genes at pre-wound, 2 DPW, and 8 DPW in Lepr^db/+ and Lepr^db/db mice (n = 7 for each group). b, c Principal component analysis (PCA) of the levels of senescence based on senescence-related gene expression at pre-wound, 2 DPW, and 8 DPW for Lepr^db/+ and Lepr^db/db mice in skin and adipose tissue. Quantitative data are presented as means and medians with IQRs and 1.5 times the IQR and are shown as box-and-whisker plots. p-values were determined using the Tukey method for one-way ANOVA (*p < 0.05).