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. 2022 Apr 5;5:310. doi: 10.1038/s42003-022-03266-3

Fig. 4. p15INK4B expression in PDGFRα + cells in subcutaneous adipose tissue during wound healing in Leprdb/+ and Leprdb/db mice.

Fig. 4

a Representative images of adipose tissue following immunostaining for PDGFRα and p15INK4B. Samples were collected at pre-wounding, 2 DPW, and 8 DPW. b, c Percentage of PDGFRα + cells (Leprdb/+pre-wounding: n = 3; Leprdb/+ 2 DPW: n = 4; Leprdb/+ 8 DPW; n = 3; Leprdb/db pre-wounding: n = 3; Leprdb/db 2 DPW: n = 3; Leprdb/db 8 DPW; n = 3) and Pdgfra mRNA levels in adipose tissue at pre-wounding, 2 DPW, and 8 DPW (Leprdb/+pre-wounding: n = 6; Leprdb/+ 2 DPW: n = 7; Leprdb/+ 8 DPW; n = 7; Leprdb/db pre-wounding: n = 7; Leprdb/db 2 DPW: n = 7; Leprdb/db 8 DPW; n = 6). d, e Percentage of PDGFRα − and p15INK4B + cells and fluorescence intensity of p15INK4B in PDGFRα + cells (Leprdb/+pre-wounding: n = 3; Leprdb/+ 2 DPW: n = 4; Leprdb/+ 8 DPW; n = 3; Leprdb/db pre-wounding: n = 3; Leprdb/db 2 DPW: n = 3; Leprdb/db 8 DPW; n = 3). Quantitative data are presented as box-and-whisker plots with IQRs and 1.5 times the IQR. p-values were determined using the Tukey method for one-way ANOVA (*p < 0.05 and **p < 0.001).