Table1.
Information of patients with diabetes and controls.
| Donor/Group | Sex | Age | DM Daignosis | HbA1c (NGSP) [%] | Diagnosis | Wound (Source of the adipose tissue) | Time post-wounding | Comorbidity | Past Medical History(PMH) | Medication |
|---|---|---|---|---|---|---|---|---|---|---|
| Non-DM1 | Male | 65 | - | - | Electric injury, Burn | Abdomen | 19 | No | Postoperative hepatoma | Celecoxib, rebamipide |
| Non-DM2 | Male | 82 | - | - | Burn | Thigh | 39 | Chronic renal impairment, dementia | Myocardial infarction, cerebral infarction, postoperative colorectal cancer | Esomeprazole magnesium hydrate, acetaminophen, aspirin, carvedilol, amlodipine besilate, amiodarone hydrochloride, silodosin |
| Non-DM3 | Male | 65 | - | - | Burn | Lower leg | 39 | Hypertension, hypercholesterolemia, narcolepsy | - | Esomeprazole magnesium hydrate, loxoprofen sodium hydrate, amoxicillin hydrate, aspirin, carvedilol, clopidogrel sulfate, vitamin B6, vitamin B12 |
| Non-DM4 | Male | 45 | - | - | Burn | Hip | 39 | Smoke inhalation | Traumatic intracranial hemorrhage | Lactulose, meropenem |
| Non-DM5 | Female | 70 | - | - | Pressure ulcer | Chest | 70 | Chronic obstructive pulmonary disease(COPD) | Breast cancer | Fluticasone furoate, umeclidinium bromide vilanterol trifenatate, cilnidipine, allopurinol, sodium risedronate hydrate, rabeprazole sodium, domperidone, syakuyaku-kanzo-to(kampo medicine) |
| Non-DM6 | Male | 21 | - | - | Pressure ulcer | Ischial region | 84 | Spinal cord injury(Paraplegia) | - | - |
| DM1 | Female | 76 | + | 7.1 | Chronic traumatic ulcer | Elbow | 11 | Thrombocytopenic purpura, atrial fibrillation, iron deficiency anemia, dementia, gastric cancer | Thoracic compression fracture | Denosumab, prednisolone (15 mg/day), fenofibrate, pilsicainide hydrochloride hydrate, vonoprazan fumarate, clotiazepam, solifenacin succinate, sodium ferrous citrate, donepezil hydrochloride, magnesium oxide |
| DM2 | Male | 64 | + | 7.3 | Burn | Thigh | 13 | Hypertension | unknown | Rikkunshito (kampo medicine), omeprazole |
| DM3 | Male | 60 | + | 5.2 | Burn | Back | 17 | Multi-hepatoma, liver cirrhosis, esophageal varices, hypertension | - | Rikkunshito (kampo medicine), insulin human (genetical recombination), micafungin sodium, ceftazidime hydrate, linezolid, lactulose |
| DM4* | Male | 60 | + | 5.2 | Burn | Abdomen | 31 | Multi-hepatoma, liver cirrhosis, esophageal varices, hypertension | - | Acetaminophen, rikkunshito (kampo medicine), insulin human (genetical recombination), furosemide, ceftazidime hydrate, linezolid, lactulose, entecavir hydrate |
| DM5 | Male | 70 | + | 11 | Fournier gangrene | Hip | 35 | Hypercholesterolemia | - | Canagliflozin hydrate, metformin hydrochloride, insulin degludec(genetical recombination), olmesartan medoxomil, pitavastatin calcium hydrate |
| DM6 | Female | 82 | + | 6.3 | Ulcer after vein harvesting | Lower leg | 64 | Gallstone, diabetic retinopathy, hypertension, hypercholesteremia | Postoperative abdominal aortic aneurysm, inflammation of mesenteric adipose tissue, ischemic enteritis, cholangitis aneurysm, interstitial lung disease | Acetaminophen, magnesium oxide, vildagliptin, sennoside A·B calcium, insulin lispro(genetical recombination), insulin glargine(genetical recombination), pilsicainide hydrochloride hydrate, aspirin, warfarin potassium, bisoprolol fumarate, vonoprazan fumarate, atorvastatin calcium hydrate |
*Same patient as DM3