Fig. 2. NSCLC PDX models represent primary tumor transcriptome and methylome features.

A Workflow for generation of NSCLC stable PDX models including primary resections and EBUS recurrences. See also Supplementary Table 1. B 5-year survival Kaplan–Meier plot of primary resected cases. C Assignment of PDXs to the 3 TCGA described LUAD transcriptome subtypes. See also Supplementary Fig. 1. D Assignment of PDXs to the 4 TCGA described LUSC transcriptome subtypes. See also Supplementary Fig. 1. E Identification of three major methylation groups among LUAD and F four major methylation groups among LUSC using unsupervised clustering of top 4000 most variable CpGs (in promoter region or within 1500 bases of the transcription start site).