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. 2022 Apr 5;13:1811. doi: 10.1038/s41467-022-29444-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A Pie chart showing 6830 human (tumor), 4423 mouse (stroma) and 2031 ambiguous human/mouse proteins detected by proteome analysis. B Tumor/stromal composition of each PDX sample shows wide range of tumor vs. stroma content. C Histological separation by unsupervised hierarchical clustering of PDXs by tumor proteome. D Differential proteome between histological types LUAD and LUSC (two-sided t-test, FDR < 0.001). E, F Significantly differential upregulated proteins (FDR < 0.001) are ranked based on fold-change (E) for LUSC and (F) LUAD.