Fig. 5. Lung LUAD and LUSC defined proteotypes associated with differences in patient survival and protein-phosphotyrosine signatures.

A, B Tumor proteome separates (A) LUAD histology PDX samples into three distinct subtypes LUAD1, LUAD2, and LUAD3 and B LUSC into two distinct subtypes LUSC1 and LUSC2. See also Supplementary Fig. 3A–J. C, D 5-year overall survival Kaplan–Meier plot shows significant survival differences between the C LUAD1 and LUAD3 groups and D the two LUSC groups. See also Supplementary Table 4. E, F Stage breakdown of E LUAD and F LUSC proteotypes. G, H Proteotypes of G LUAD and H LUSC have distinctive protein-pY profiles.