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. 2022 Apr 5;12:5696. doi: 10.1038/s41598-022-09748-y

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Example posterior subregion segmentations of T1-weighted MRI sequence (left panels), whole brain radiotracer uptake at baseline (middle panels) and post-inoculation (right panels) in Participant 4 (top row) and Participant 7 (bottom row). Segmentation map: blue—anterior grey matter; red—anterior white matter; brown—deep grey matter; yellow/orange—corpus callosum (yellow indicates splenium); purple—posterior grey matter; green—posterior white matter. Participant 4: Increased radiotracer uptake is evident globally on post-inoculation imaging. Participant 7: Decreased radiotracer uptake is evident globally on post-inoculation imaging.