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. 2022 Apr 5;13(4):306. doi: 10.1038/s41419-022-04754-4

Fig. 6. Nogo-B overexpression upregulated the Notch signaling pathway.

Fig. 6

A Heat map of genes related to the Notch pathway with RNA-seq for CMECs from AAV-NC or AAV-Nogo-B-infected mice after MI. B GSEA analyses of the gene set upregulated by Nogo-B overexpression in CMECs. C Protein levels of Notch and Hes1 in the AAV-Nogo-B and AAV-NC infected hearts after MI in border (BZ) and remote zone (RZ) of infarcted hearts (n = 5). *P < 0.05, **P < 0.01 versus sham group. D Protein levels of Notch and Hes1 in ECs treated with DAPT and siNotch (n = 5). *P < 0.05, **P < 0.01 versus Ad-NC group. ns, not significant. Data were expressed as mean ± SEM. Two-way ANOVA (C, D).